amantadine mechanism of action dopamine

Pharmacodynamics. Paroxetine treats the symptoms of depression, various anxiety disorders, posttraumatic stress disorder, obsessive-compulsive disorder, and the vasomotor symptoms of menopause via the inhibition of serotonin reuptake. 18 Due its serotonergic Metabolism. Amantadine: Amantadine may decrease the excretion rate of Carbamazepine which could result in a higher serum level. Hepatic. It is primarily used to manage the symptoms of Parkinson's disease, but it does not slow down the disease or stop it from getting worse. As these receptors have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity, the symptoms of pain are temporarily reduced. Methyldopa is a centrally-acting alpha-2 adrenergic agonist used to manage hypertension alone or in combination with hydrochlorothiazide, and to treat hypertensive crises.. Generic Name Methyldopa DrugBank Accession Number DB00968 Background. Mechanism of action. Mefenamic acid binds the prostaglandin synthetase receptors COX-1 and COX-2, inhibiting the action of prostaglandin synthetase. Hypericum perforatum, known as St. John's wort, is a flowering plant in the family Hypericaceae and the type species of the genus Hypericum.. 11 It is used to restore serotonergic function in the treatment of depression and anxiety. 2008;(184):261-88. Pharmacodynamics. The serum concentration of Amantadine can be increased when it is combined with Metformin. Generic Name Escitalopram DrugBank Accession Number DB01175 Background. It is an amine synthesized by removing a carboxyl group from a molecule of its precursor Paroxetine treats the symptoms of depression, various anxiety disorders, posttraumatic stress disorder, obsessive-compulsive disorder, and the vasomotor symptoms of menopause via the inhibition of serotonin reuptake. Mechanism of action. Vd: 0.9 L/kg. It has been shown to cause an increase in dopamine release in the animal brain, and does not possess anticholinergic activity. 12,13 Patients should be counselled Dopamine is the chemical messenger responsible for transmitting signals between the substantia nigra and the next relay station of the brain, the corpus striatum, to produce smooth, purposeful movement. Mechanism of action Moussa B.H. After extraction from coca leaves and further processing into cocaine hydrochloride (powdered cocaine), the drug may be snorted, Generic Name Escitalopram DrugBank Accession Number DB01175 Background. Clozapine's antagonism of muscarinic M1-5 receptors may explain its anticholinergic effects. Mechanism of action Parkinson's disease. Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic citalopram. Cocaine (from French: cocane, from Spanish: coca, ultimately from Quechua: kka) is an addictive stimulant drug obtained from the leaves of two Coca species native to South America, Erythroxylum coca and Erythroxylum novogranatense. Gentamicin is a bactericidal aminoglycoside that was discovered and isolated from Micromonospora purpurea in 1963. A dopamine agonist (DA) is a compound that activates dopamine receptors. It possesses structural similarity to several neurotransmitters, and has biological activity as a vasoconstrictor.. 1 The final subtype, alpha-1B, are most common in the aorta and spleen. Enzymes induced: CYP1A2, CYP2B6, CYP3A4; induces its own metabolism (chronic) The mechanism of action of amantadine in the treatment of Parkinson's disease and drug-induced extrapyramidal reactions is not known. Hypericum perforatum, known as St. John's wort, is a flowering plant in the family Hypericaceae and the type species of the genus Hypericum.. Mefenamic acid binds the prostaglandin synthetase receptors COX-1 and COX-2, inhibiting the action of prostaglandin synthetase. Mechanism of action. Youdim identified it as a potential drug for Parkinson's disease, and Amantadine probably does not inhibit monoamine oxidase (MAO) enzyme. Noradrenaline acts on both alpha-1 and alpha-2 adrenergic receptors to cause vasoconstriction. Mechanism of action. Methyldopa is a centrally-acting alpha-2 adrenergic agonist used to manage hypertension alone or in combination with hydrochlorothiazide, and to treat hypertensive crises.. Generic Name Methyldopa DrugBank Accession Number DB00968 Background. Mechanism of Action. Dopamine constitutes about 80% of the catecholamine content in the brain. Generic Name Gentamicin DrugBank Accession Number DB00798 Background. Amantadine probably does not inhibit monoamine oxidase (MAO) enzyme. Carbidopa/levodopa, also known as levocarb and co-careldopa, is the combination of the two medications carbidopa and levodopa. Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic citalopram. Gilsbach R, Hein L: Presynaptic metabotropic receptors for acetylcholine and adrenaline/noradrenaline. Antagonism at receptors other than dopamine and 5HT 2 with similar receptor affinities may explain some of the other therapeutic and side effects of clozapine. The serum concentration of Dopamine can be increased when it is combined with Metformin. Pregabalin is structurally similar to gamma-aminobutyric acid (GABA) - an inhibitory neurotransmitter. 20 Although as per the FDA Label the mechanism of action has not been It is an amine synthesized by removing a carboxyl group from a molecule of its precursor Doripenem: Metformin may decrease the excretion rate of Doripenem which could result in a higher serum level. The serum concentration of Amantadine can be increased when it is combined with Metformin. Identification Summary. Peak plasma time: 2-4 hr. Label,17 It also increases the risk of developing a gastrointestinal ulcer by inhibiting the production of protective mucus in the stomach.. It is an amine synthesized by removing a carboxyl group from a molecule of its precursor Hepatic. 13 It may be used to manage neuropathic pain, postherpetic neuralgia, and fibromyalgia among other conditions. Antagonism at receptors other than dopamine and 5HT 2 with similar receptor affinities may explain some of the other therapeutic and side effects of clozapine. Pharmacodynamics. A dopamine agonist (DA) is a compound that activates dopamine receptors. Mechanism of action Parkinson's disease. Generic Name Pregabalin DrugBank Accession Number DB00230 Background. Dopamine is an essential and critical neurotransmitter produced in the substantia nigra and ventral tegmental regions of the brain. It can take two to three weeks of treatment before benefits are seen. Diclofenac reduces inflammation and by extension reduces nociceptive pain and combats fever. It possesses structural similarity to several neurotransmitters, and has biological activity as a vasoconstrictor.. Normally, the neurons in this area produce dopamine. Possibly a hybrid between H. maculatum and H. attenuatum, the species can be found across temperate areas of Eurasia and has been introduced as an invasive weed to much of North and South America, as well as South Africa and Australia. The mechanism of action of amantadine in the treatment of Parkinson's disease and drug-induced extrapyramidal reactions is not known. Tamsulosin is an alpha adrenoceptor blocker with specificity for the alpha-1A and alpha-1D subtypes, which are more common in the prostate and submaxillary tissue. Dopamine is the chemical messenger responsible for transmitting signals between the substantia nigra and the next relay station of the brain, the corpus striatum, to produce smooth, purposeful movement. 1 The final subtype, alpha-1B, are most common in the aorta and spleen. Mechanism of action. Mefenamic acid binds the prostaglandin synthetase receptors COX-1 and COX-2, inhibiting the action of prostaglandin synthetase. Methyldopa, or -methyldopa, is a centrally acting sympatholytic agent and an antihypertensive Diclofenac reduces inflammation and by extension reduces nociceptive pain and combats fever. The serum concentration of Amantadine can be increased when it is combined with Metformin. Rasagiline (Azilect, Azipron) is an irreversible inhibitor of monoamine oxidase-B used as a monotherapy to treat symptoms in early Parkinson's disease or as an adjunct therapy in more advanced cases.. Mechanism of action Identification Summary. Antagonism at receptors other than dopamine and 5HT 2 with similar receptor affinities may explain some of the other therapeutic and side effects of clozapine. It has been shown to cause an increase in dopamine release in the animal brain, and does not possess anticholinergic activity. Mechanism of action. Generic Name Escitalopram DrugBank Accession Number DB01175 Background. Enzymes induced: CYP1A2, CYP2B6, CYP3A4; induces its own metabolism (chronic) The antiparkinsonian drugs amantadine, bromocriptine, and levodopa combined with carbidopa (e.g., Sinemet) have varied mechanisms of action, but all ultimately serve to increase dopamine levels in the brain. 1990 Nov;13(11):764-72. 5,8 Gentamicin is effective against both gram-positive and 1 Tamsulosin binds to alpha-1A receptors 3.9-38 times more selectively than alpha-1B and 3-20 times more 7 It is one of the most frequently prescribed aminoglycosides due to its spectrum of activity, low cost, and availability. After extraction from coca leaves and further processing into cocaine hydrochloride (powdered cocaine), the drug may be snorted, 13 It may be used to manage neuropathic pain, postherpetic neuralgia, and fibromyalgia among other conditions. Cocaine (from French: cocane, from Spanish: coca, ultimately from Quechua: kka) is an addictive stimulant drug obtained from the leaves of two Coca species native to South America, Erythroxylum coca and Erythroxylum novogranatense. 13 It may be used to manage neuropathic pain, postherpetic neuralgia, and fibromyalgia among other conditions. The serum concentration of Dopamine can be increased when it is combined with Metformin. Mechanism of action. As these receptors have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity, the symptoms of pain are temporarily reduced. Pharmacodynamics. 19. Absorption. The mechanism of action of amantadine in the treatment of Parkinson's disease and drug-induced extrapyramidal reactions is not known. It is primarily used to manage the symptoms of Parkinson's disease, but it does not slow down the disease or stop it from getting worse. 20 Although as per the FDA Label the mechanism of action has not been Mechanism of action. Dopamine agonists are used in Parkinsons disease and, to a lesser Pharmacodynamics. 26,29,30 The onset of action of paroxetine is reported to be approximately 6 weeks. Drugs with an unknown mechanism of action for PD: Amantadine: Symmetrek: Moussa B.H. Mechanism of Action. Adenosine is indicated as an adjunct to thallium-201 in myocardial perfusion scintigraphy and also indicated for conversion of sinus rhythm of paroxysmal supraventricular tachycardia. carbamazepine is thought to increase dopamine turnover and increase GABA transmission, treating manic and depressive symptoms. Dopamine constitutes about 80% of the catecholamine content in the brain. It is used medicinally for treatment of acute migraine Drugs with an unknown mechanism of action for PD: Amantadine: Symmetrek: Gentamicin is a bactericidal aminoglycoside that was discovered and isolated from Micromonospora purpurea in 1963. Diclofenac inhibits cyclooxygenase-1 and -2, the enzymes responsible 1 Tamsulosin binds to alpha-1A receptors 3.9-38 times more selectively than alpha-1B and 3-20 times more Adenosine is indicated as an adjunct to thallium-201 in myocardial perfusion scintigraphy and also indicated for conversion of sinus rhythm of paroxysmal supraventricular tachycardia. Dopamine produces positive chronotropic and inotropic effects on the myocardium, resulting in increased heart rate and cardiac contractility. Dopamine constitutes about 80% of the catecholamine content in the brain. 12,13 Adenosine has a short duration of action as the half life is 10 seconds, and a wide therapeutic window. Amantadine is a weak antagonist of the NMDA-type glutamate receptor, increases dopamine release, and blocks dopamine reuptake. Metabolism. Mechanism of action. Clozapine's antagonism of muscarinic M1-5 receptors may explain its anticholinergic effects. Unknown; not sympathomimetic; may increase dopamine levels in the brain by binding to the dopamine transporter and inhibiting dopamine reuptake. 7 It is one of the most frequently prescribed aminoglycosides due to its spectrum of activity, low cost, and availability. Amantadine is a weak antagonist of the NMDA-type glutamate receptor, increases dopamine release, and blocks dopamine reuptake. 1 The final subtype, alpha-1B, are most common in the aorta and spleen. Ergotamine, sold under the brand names Cafergot (with caffeine) and Ergomar among others, is an ergopeptine and part of the ergot family of alkaloids; it is structurally and biochemically closely related to ergoline. Amantadine: Amantadine may decrease the excretion rate of Carbamazepine which could result in a higher serum level. Mechanism of action. The racemic form of the drug was invented by Aspro Nicholas in the early 1970s. Mechanism of action. Mechanism of Action. Amantadine probably does not inhibit monoamine oxidase (MAO) enzyme. Hepatic. Unknown; not sympathomimetic; may increase dopamine levels in the brain by binding to the dopamine transporter and inhibiting dopamine reuptake. Normally, the neurons in this area produce dopamine. Dopaminergic projection function in the nigrostriatal, mesolimbic, and mesocortical systems. Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is a neuromodulatory molecule that plays several important roles in cells.It is an organic chemical of the catecholamine and phenethylamine families. The mechanism of its antiparkinsonian effect is poorly understood. Bromantane, sold under the brand name Ladasten, is an atypical psychostimulant and anxiolytic drug of the adamantane family related to amantadine and memantine which is used in Russia in the treatment of neurasthenia.Although the effects of the bromantane have been determined to be dependent on the dopaminergic and possibly serotonergic neurotransmitter systems, its Nash DT: Alpha-adrenergic blockers: mechanism of action, blood pressure control, and effects of lipoprotein metabolism. Handb Exp Pharmacol. Dopamine is a precursor to norepinephrine in noradrenergic nerves and is also a neurotransmitter in certain areas of the central nervous system. Diclofenac inhibits cyclooxygenase-1 and -2, the enzymes responsible carbamazepine is thought to increase dopamine turnover and increase GABA transmission, treating manic and depressive symptoms. 11 It is used to restore serotonergic function in the treatment of depression and anxiety. As these receptors have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity, the symptoms of pain are temporarily reduced. Pharmacodynamics. This occurs both in the peripheral circulation and in the central nervous system after levodopa has crossed the blood brain barrier. Distribution. Dopaminergic projection function in the nigrostriatal, mesolimbic, and mesocortical systems. Gilsbach R, Hein L: Presynaptic metabotropic receptors for acetylcholine and adrenaline/noradrenaline. It also acts as an antagonist of 5-HT 2 and -adrenergic receptors with high affinity.The compound is historically a morphine decomposition product made by boiling Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is a neuromodulatory molecule that plays several important roles in cells.It is an organic chemical of the catecholamine and phenethylamine families. Label,17 It also increases the risk of developing a gastrointestinal ulcer by inhibiting the production of protective mucus in the stomach.. Rasagiline (Azilect, Azipron) is an irreversible inhibitor of monoamine oxidase-B used as a monotherapy to treat symptoms in early Parkinson's disease or as an adjunct therapy in more advanced cases.. Its effect in-vitro is often limited to the increasing of blood pressure through antagonising alpha-1 and alpha-2 receptors and causing a resultant increase in systemic vascular resistance. It is used medicinally for treatment of acute migraine The antiparkinsonian drugs amantadine, bromocriptine, and levodopa combined with carbidopa (e.g., Sinemet) have varied mechanisms of action, but all ultimately serve to increase dopamine levels in the brain. Mechanism of action. Tamsulosin is an alpha adrenoceptor blocker with specificity for the alpha-1A and alpha-1D subtypes, which are more common in the prostate and submaxillary tissue. Doripenem: Metformin may decrease the excretion rate of Doripenem which could result in a higher serum level. Ergotamine, sold under the brand names Cafergot (with caffeine) and Ergomar among others, is an ergopeptine and part of the ergot family of alkaloids; it is structurally and biochemically closely related to ergoline. Diclofenac reduces inflammation and by extension reduces nociceptive pain and combats fever. Apomorphine, sold under the brand name Apokyn among others, is a type of aporphine having activity as a non-selective dopamine agonist which activates both D 2-like and, to a much lesser extent, D 1-like receptors. Hypericum perforatum, known as St. John's wort, is a flowering plant in the family Hypericaceae and the type species of the genus Hypericum.. The racemic form of the drug was invented by Aspro Nicholas in the early 1970s. Vd: 0.9 L/kg. The mechanism of its antiparkinsonian effect is poorly understood. Amantadine is a weak antagonist of the NMDA-type glutamate receptor, increases dopamine release, and blocks dopamine reuptake. Mechanism of action. Generic Name Gentamicin DrugBank Accession Number DB00798 Background. After extraction from coca leaves and further processing into cocaine hydrochloride (powdered cocaine), the drug may be snorted, Youdim identified it as a potential drug for Parkinson's disease, and Absorption. Dopamine receptor D 2, also known as D2R, is a protein that, in humans, is encoded by the DRD2 gene.After work from Paul Greengard's lab had suggested that dopamine receptors were the site of action of antipsychotic drugs, several groups, including those of Solomon Snyder and Philip Seeman used a radiolabeled antipsychotic drug to identify what is now known as the dopamine Tamsulosin is an alpha adrenoceptor blocker with specificity for the alpha-1A and alpha-1D subtypes, which are more common in the prostate and submaxillary tissue. There are two families of dopamine receptors, D 2-like and D 1-like, and they are all G protein-coupled receptors.D 1 - and D 5-receptors belong to the D 1-like family and the D 2-like family includes D 2, D 3 and D 4 receptors. 12,13 Adenosine has a short duration of action as the half life is 10 seconds, and a wide therapeutic window. It is a derivate of adamantane, like a similar drug rimantadine. Metabolism. Possibly a hybrid between H. maculatum and H. attenuatum, the species can be found across temperate areas of Eurasia and has been introduced as an invasive weed to much of North and South America, as well as South Africa and Australia. carbamazepine is thought to increase dopamine turnover and increase GABA transmission, treating manic and depressive symptoms. Dopaminergic projection function in the nigrostriatal, mesolimbic, and mesocortical systems. Clin Cardiol. Pharmacodynamics. 11 It is used to restore serotonergic function in the treatment of depression and anxiety. 26,29,30 The onset of action of paroxetine is reported to be approximately 6 weeks. Ergotamine, sold under the brand names Cafergot (with caffeine) and Ergomar among others, is an ergopeptine and part of the ergot family of alkaloids; it is structurally and biochemically closely related to ergoline. 26,29,30 The onset of action of paroxetine is reported to be approximately 6 weeks. Bromantane, sold under the brand name Ladasten, is an atypical psychostimulant and anxiolytic drug of the adamantane family related to amantadine and memantine which is used in Russia in the treatment of neurasthenia.Although the effects of the bromantane have been determined to be dependent on the dopaminergic and possibly serotonergic neurotransmitter systems, its Rasagiline (Azilect, Azipron) is an irreversible inhibitor of monoamine oxidase-B used as a monotherapy to treat symptoms in early Parkinson's disease or as an adjunct therapy in more advanced cases.. 19. Mechanism of action. It is a derivate of adamantane, like a similar drug rimantadine. Mechanism of action. Mechanism of action. Pharmacodynamics. Carbidopa/levodopa, also known as levocarb and co-careldopa, is the combination of the two medications carbidopa and levodopa. Dopamine agonists are used in Parkinsons disease and, to a lesser It is used medicinally for treatment of acute migraine Methyldopa is a centrally-acting alpha-2 adrenergic agonist used to manage hypertension alone or in combination with hydrochlorothiazide, and to treat hypertensive crises.. Generic Name Methyldopa DrugBank Accession Number DB00968 Background. 1990 Nov;13(11):764-72. Enzymes induced: CYP1A2, CYP2B6, CYP3A4; induces its own metabolism (chronic) Clin Cardiol. Pregabalin is structurally similar to gamma-aminobutyric acid (GABA) - an inhibitory neurotransmitter. The racemic form of the drug was invented by Aspro Nicholas in the early 1970s. Generic Name Pregabalin DrugBank Accession Number DB00230 Background. 18 Due its serotonergic 19. 18,19,20 Escitalopram is approximately 150 times more potent than citaloprams R-enantiomer and is Methyldopa, or -methyldopa, is a centrally acting sympatholytic agent and an antihypertensive Apomorphine, sold under the brand name Apokyn among others, is a type of aporphine having activity as a non-selective dopamine agonist which activates both D 2-like and, to a much lesser extent, D 1-like receptors. Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic citalopram. Youdim identified it as a potential drug for Parkinson's disease, and Protein bound: 60%. Dopamine is an essential and critical neurotransmitter produced in the substantia nigra and ventral tegmental regions of the brain. 5,8 Gentamicin is effective against both gram-positive and It is taken by mouth. 18 Due its serotonergic Mechanism of action. Dopamine is the chemical messenger responsible for transmitting signals between the substantia nigra and the next relay station of the brain, the corpus striatum, to produce smooth, purposeful movement. Normally, the neurons in this area produce dopamine. Pharmacodynamics. Label,17 It also increases the risk of developing a gastrointestinal ulcer by inhibiting the production of protective mucus in the stomach.. 7 It is one of the most frequently prescribed aminoglycosides due to its spectrum of activity, low cost, and availability. Adenosine is indicated as an adjunct to thallium-201 in myocardial perfusion scintigraphy and also indicated for conversion of sinus rhythm of paroxysmal supraventricular tachycardia. Absorption. Possibly a hybrid between H. maculatum and H. attenuatum, the species can be found across temperate areas of Eurasia and has been introduced as an invasive weed to much of North and South America, as well as South Africa and Australia. Pharmacodynamics. Generic Name Gentamicin DrugBank Accession Number DB00798 Background. Nash DT: Alpha-adrenergic blockers: mechanism of action, blood pressure control, and effects of lipoprotein metabolism. Pharmacodynamics. Cocaine (from French: cocane, from Spanish: coca, ultimately from Quechua: kka) is an addictive stimulant drug obtained from the leaves of two Coca species native to South America, Erythroxylum coca and Erythroxylum novogranatense. Dopamine receptor D 2, also known as D2R, is a protein that, in humans, is encoded by the DRD2 gene.After work from Paul Greengard's lab had suggested that dopamine receptors were the site of action of antipsychotic drugs, several groups, including those of Solomon Snyder and Philip Seeman used a radiolabeled antipsychotic drug to identify what is now known as the dopamine Dopamine is a precursor to norepinephrine in noradrenergic nerves and is also a neurotransmitter in certain areas of the central nervous system. Dopamine produces positive chronotropic and inotropic effects on the myocardium, resulting in increased heart rate and cardiac contractility. Methyldopa, or -methyldopa, is a centrally acting sympatholytic agent and an antihypertensive Peak plasma time: 2-4 hr. Generic Name Pregabalin DrugBank Accession Number DB00230 Background. It also acts as an antagonist of 5-HT 2 and -adrenergic receptors with high affinity.The compound is historically a morphine decomposition product made by boiling Moussa B.H. 12,13 Patients should be counselled Bromantane, sold under the brand name Ladasten, is an atypical psychostimulant and anxiolytic drug of the adamantane family related to amantadine and memantine which is used in Russia in the treatment of neurasthenia.Although the effects of the bromantane have been determined to be dependent on the dopaminergic and possibly serotonergic neurotransmitter systems, its Doripenem: Metformin may decrease the excretion rate of Doripenem which could result in a higher serum level. There are two families of dopamine receptors, D 2-like and D 1-like, and they are all G protein-coupled receptors.D 1 - and D 5-receptors belong to the D 1-like family and the D 2-like family includes D 2, D 3 and D 4 receptors. 20 Although as per the FDA Label the mechanism of action has not been Diclofenac inhibits cyclooxygenase-1 and -2, the enzymes responsible Mechanism of action Parkinson's disease. Pharmacodynamics. Mechanism of action A dopamine agonist (DA) is a compound that activates dopamine receptors. Dopamine receptor D 2, also known as D2R, is a protein that, in humans, is encoded by the DRD2 gene.After work from Paul Greengard's lab had suggested that dopamine receptors were the site of action of antipsychotic drugs, several groups, including those of Solomon Snyder and Philip Seeman used a radiolabeled antipsychotic drug to identify what is now known as the dopamine It has been shown to cause an increase in dopamine release in the animal brain, and does not possess anticholinergic activity. 12,13 Adenosine has a short duration of action as the half life is 10 seconds, and a wide therapeutic window. Distribution. The antiparkinsonian drugs amantadine, bromocriptine, and levodopa combined with carbidopa (e.g., Sinemet) have varied mechanisms of action, but all ultimately serve to increase dopamine levels in the brain. 18,19,20 Escitalopram is approximately 150 times more potent than citaloprams R-enantiomer and is 1 Tamsulosin binds to alpha-1A receptors 3.9-38 times more selectively than alpha-1B and 3-20 times more

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