synaffix glycoconnect

This is the 3 rd ADC built with GlycoConnect ADC technology to enter the clinic. Under the terms of the agreement, Miracogen has been granted non-exclusive rights to Synaffixs proprietary GlycoConnect and HydraSpace ADC technologies for use Synaffix has established a simple, yet powerful, clinical-stage platform technology enabling best-in-class AMSTERDAM--(BUSINESS WIRE)--Synaffix BV, a biotechnology company exclusively focused on the development of industry-leading antibody-drug conjugate (ADC) Synaffix is eligible to receive upfront and milestone payments on a per-target basis with a projected total deal value of $295 million, plus royalties. Synaffix will closely support ProfoundBios research activities and be responsible for the manufacturing of components that are specifically related to its proprietary Synaffix B.V., a biotechnology company focused on commercializing its clinical-stage platform technology for the development of antibody-drug conjugates (ADCs) with best-in In The technologies licensed from Synaffix include GlycoConnect, HydraSpace, and multiple toxSYN linker-payloads, which allow for the drug-to-antibody About About Synaffix BV. This is the 3rd ADC built with GlycoConnect ADC technology to enter the clinic. The technology licensed from Synaffix include GlycoConnect(TM), HydraSpace(TM), and multiple toxSYN(TM) linker-payloads, which allow for the drug-to Its antibody conjugation technology GlycoConnect enables the GlycoConnect replaces the existing antibody glycan with a therapeutic payload. Based on Synaffixs seamless partnering model, we could rapidly combine Synaffixs ADC technologies with Innovents antibody, generate compelling research data and Under the terms of the agreement, Miracogen has been granted non-exclusive rights to Synaffixs proprietary GlycoConnect and HydraSpace ADC technologies for use in this second clinical candidate. The technologies licensed from Synaffix include GlycoConnect, HydraSpace, and multiple toxSYN linker-payloads, which allow for the drug-to-antibody SynAffix Raises Series A Investment Round to Advance its GlycoConnect Technology for Creating Next-Generation ADCs. Expanded deal focuses on Synaffixs GlycoConnect site-specific ADC bioconjugation technology and adds license options for six new programs to existing deal Peter van de Sande, Chief Executive Officer of Synaffix, said: "We are delighted to expand our collaboration with Mersana, a leader in ADC innovation, who will be utilizing our About Synaffix B.V. Synaffix B.V. is a biotechnology company that enables ADC product candidates using its clinical-stage, site-specific ADC technology platform. Floris van Delft, Ph.D., Chief Scientific Officer of Synaffix, said: "We are thrilled with the successful ADC data, expansion of this license agreement and to see a leading global pharmaceutical company like Kyowa Kirin deploying Synaffix ADC technology in order to fulfill its mission of improving the lives of patients with cancer worldwide." The growing experience of Synaffix and its collaboration partners continues to confirm the ability of GlycoConnect and HydraSpace to consistently generate ADCs with Synaffix utilizes GlycoConnect, a proprietary technology based on the native glycan of monoclonal antibodies, which is used as a privileged conjugation site for ADCs. Synaffix is eligible to receive upfront and milestone payments on a per-target basis with a projected total deal value of $295 million, plus royalties. Synaffixs proprietary ADC technology platform consists of GlycoConnect, HydraSpace and toxSYN linker-payload technologies. Peter van de Sande, Chief Executive Officer of Synaffix, said: "We are delighted to expand our collaboration with Mersana, a leader in ADC innovation, who will be utilizing our Synaffix is eligible to receive upfront, milestone and royalty payments tied to this new program. Founded in 2010, Synaffix is a biotech company with a clinical-stage platform technology that enables best-in-class antibody-drug conjugates (ADCs ), bispecific antibodies and other targeted therapeutics under a technology out-licensing business model. In addition to GlycoConnect ADCs were generated by conjugation of SYNtecan E to antibodies and evaluated for efficacy and tolerability. The proprietary GlycoConnect technology of Synaffix is a platform ADC technology that utilizes proprietary enzymes and metal-free click conjugation to stably attach With its clinical-stage platform technology, Synaffix has established itself as the preferred technology provider enabling best-in-class targeted cancer therapeutics. Synaffix, Oss, Netherlands. Oss, The Netherlands 18 February 2014 SynAffix B.V., a Develope a robust and efficient manufacturing process for a site-specific ADC in 6month, using GlycoConnect technology licensed from Synaffix; Author and reviewer of IND dossiers (process sections) for application in China and US. Under the terms of the Search for other works by this author on: This Site. Under the licensing agreement, MacroGenics will gain access to Synaffixs clinical stage GlycoConnect antibody conjugation technology, HydraSpace polar spacer Complete tumor regression was observed in a mouse xenograft study (BT-474) after a single dose, while safety studies in mouse corroborated high tolerability of SYNtecan E ADCs. Expanded deal focuses on Synaffixs GlycoConnect site-specific ADC bioconjugation technology and adds Amsterdam, the Netherlands, October 20, 2016 / B3C newswire / --Synaffix BV announced today it has entered into a Commercial License Agreement with ADC Therapeutics for its proprietary GlycoConnect and HydraSpace site-specific antibody-drug conjugate technologies.Under the terms of the agreement, ADC Therapeutics has been Synaffix utilizes GlycoConnect, a proprietary technology based on the native glycan of monoclonal antibodies, which is used as a privileged conjugation site for ADCs. About GlycoConnect and HydraSpace Platforms. Biotechnology company, Synaffix B.V. enters into a technology agreement with MacroGenics (MGNX) to gain access to Synaffix's clinical stage GlycoConnect antibody Synaffix Announces $1 Billion Deal Expansion with Mersana. Amsterdam, the Netherlands, October 20, 2016 / B3C newswire / --Synaffix BV announced today it has entered into a Commercial License Agreement with ADC Therapeutics Founded in 2010, Synaffix is a biotech company with a clinical-stage platform technology that enables best-in-class antibody-drug conjugates Synaffix signs out-licensing deal with Synaffix B.V. is a biotechnology company that enables ADC product candidates using its clinical-stage, site-specific ADC technology platform. The technology licensed from Synaffix include GlycoConnect, HydraSpace, and multiple toxSYN linker-payloads, which allow for the drug-to-antibody ratio (DAR) to be Synaffix B.V. is a biotechnology company that enables ADC product candidates using its clinical-stage, site-specific ADC technology platform based on GlycoConnect, The experience of Synaffix and its partners has consistently confirmed that, in preclinical models, our proprietary GlycoConnect and HydraSpace technologies Antibody-drug conjugates (ADCs) are increasingly powerful medicines for targeted cancer therapy. Further financial details were not disclosed. Inspired by the trend to further improve their therapeutic index by generation of In addition, a The proprietary GlycoConnect technology of Synaffix is a platform ADC technology that utilizes proprietary enzymes and metal-free click conjugation to stably attach Under the terms of the agreement, Synaffix will provide all the necessary proprietary ADC technologies including GlycoConnect , HydraSpace and one of its The Netherlands-based Synaffix, a biotechnology company that has developed a proprietary site-specific platform technology to enable differentiated antibody-drug conjugates In The proprietary GlycoConnect technology of Synaffix is a platform ADC technology that utilizes proprietary enzymes and metal-free click conjugation to stably attach PubMed. Optimum Strategic Communications Hollie Vile, Stella Lempidaki, Vici Application to trastuzumab and maytansine, both components of the marketed ADC Kadcyla, demonstrate a favorable in vitro and in vivo efficacy for GlycoConnect ADC. This is the 3 rd ADC built with GlycoConnect ADC technology to enter the clinic. In addition to GlycoConnect and HydraSpace technology, the toxSYN linker-payload platform rounds out a fully complementary technology platform that enables any company with an antibody to develop proprietary best-in-class ADC products under a single license from Synaffix. Using Synaffixs platform, we hope to develop an additional ADC product candidate with an enhanced therapeutic index, and ultimately benefit cancer patients. The clinical-stage GlycoConnect and HydraSpace technologies enable best-in-class ADCs with significantly enhanced efficacy and tolerability. In addition to Synaffix B.V. Anthony DeBoer Vice President, Business Development bd@synaffix.com. Both GlycoConnect and HydraSpace are clinical-stage technologies that enable best-in-class ADCs with significantly enhanced efficacy and tolerability. Earlier today Abzena confirmed that it had successfully completed a technology transfer and scalability evaluation using the Synaffixs technologies of GlycoConnect, site Synaffix signed a licensing agreement with Shanghai Miracogen (now fully owned by The Synaffix technology platforms include GlycoConnect, the site-specific and stable antibody conjugation Synaffix utilizes GlycoConnect, a proprietary technology based on the native glycan of monoclonal antibodies, which is used as a privileged conjugation site for ADCs. Earbuds 3 ProATWS46dB Google Scholar. Author & Article Information GlycoConnect ADCs based on With the granting of this patent, Synaffix has secured end-to-end patent protection of its ADC technology platform, embodied by a growing portfolio of granted patents that now cover all three core areas of Synaffix ADC technology including GlycoConnect, HydraSpace and metal-free click chemistry. At the same time, Synaffix will support MacroGenics' research activities and be responsible for the manufacturing of components that are specifically related to its proprietary Synaffix signed an licensing agreement with Shanghai Miracogen (now fully owned by LEPU At the same time, Synaffix will support MacroGenics' research activities and be responsible for the manufacturing of components that are specifically related to its proprietary Synaffix is a biotechnology company focused on the development of antibody-drug conjugates (ADCs). Synaffix BV is a biotechnology company that enables highly competitive antibody-drug conjugate (ADC) product candidates using its site-specific ADC The technology, termed GlycoConnect, is applicable to any IgG isotype irrespective of glycosylation profile.

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